publications

2026

1. AdvSci

   Beyond Transconductance: Cell-Polymer Coupling Determines Fidelity in Action Potential Recording via Electrolyte-Gated Polymer Transistors

   Giulia Zoe Zemignani, E. Mancinelli, Gabriele Tullii, Aleksandr Khudiakov, C. Bortolotti, S. Tanwar, Peter J. Schwartz, Luca Sala, Maria Rosa Antognazza, Mario Caironi, and Adrica Kyndiah

   Advanced Science, 2026

   Bib DOI

   @article{zemignani2026beyond,
     title = {Beyond Transconductance: Cell-Polymer Coupling Determines Fidelity in Action Potential Recording via Electrolyte-Gated Polymer Transistors},
     author = {Zemignani, Giulia Zoe and Mancinelli, E. and Tullii, Gabriele and Khudiakov, Aleksandr and Bortolotti, C. and Tanwar, S. and Schwartz, Peter J. and Sala, Luca and Antognazza, Maria Rosa and Caironi, Mario and Kyndiah, Adrica},
     journal = {Advanced Science},
     pages = {e2520122},
     year = {2026},
     doi = {10.1002/advs.202520122},
     dimensions = {true}
   }

2. ESWA

   VAE-MOTION: A deep generative model for cardiomyocyte contractility analysis for improving drug efficacy evaluation

   G. Curci, P. Casti, Luca Sala, M. Brescia, P. Cascarano, M. D’Orazio, J. Filippi, G. Antonelli, A. Mencattini, M. Mastrangeli, Berend J. Meer, and E. Martinelli

   Expert Systems with Applications, 2026

   Bib DOI

   @article{curci2026vaemotion,
     title = {VAE-MOTION: A deep generative model for cardiomyocyte contractility analysis for improving drug efficacy evaluation},
     author = {Curci, G. and Casti, P. and Sala, Luca and Brescia, M. and Cascarano, P. and D'Orazio, M. and Filippi, J. and Antonelli, G. and Mencattini, A. and Mastrangeli, M. and van Meer, Berend J. and Martinelli, E.},
     journal = {Expert Systems with Applications},
     volume = {299},
     pages = {130302},
     year = {2026},
     doi = {10.1016/j.eswa.2025.130302},
     dimensions = {true}
   }

2025

1. medRxiv

   Genetic variants risk assessment for Long QT Syndrome through machine learning and multielectrode array recordings

   Aleksandr Khudiakov, Manuela Mura, Federica Giannetti, Vladislav Leonov, C. Alberio, M. Eskandr,  others, and Luca Sala^#

   medRxiv, 2025

   Bib DOI

   @article{khudiakov2025genetic,
     title = {Genetic variants risk assessment for Long QT Syndrome through machine learning and multielectrode array recordings},
     author = {Khudiakov, Aleksandr and Mura, Manuela and Giannetti, Federica and Leonov, Vladislav and Alberio, C. and Eskandr, M. and others and Sala, Luca},
     journal = {medRxiv},
     year = {2025},
     doi = {10.1101/2025.03.25.25324187},
     status = {corresponding}
   }

2. NatComm

   Non-invasive action potential recordings using printed electrolyte-gated polymer field-effect transistors

   Adrica Kyndiah, Giulia Zoe Zemignani, Carlotta Ronchi, Gabriele Tullii, Aleksandr Khudiakov, Giuseppina Iachetta, Stefano Chiodini, Rosalia Moreddu, Fabrizio Antonio Viola, Peter J. Schwartz, Gabriel Gomila, Francesco De Angelis, Luca Sala^#, Maria Rosa Antognazza, and Mario Caironi

   Nature Communications, 2025

   Bib DOI

   @article{kyndiah_non-invasive_2025,
     title = {Non-invasive action potential recordings using printed electrolyte-gated polymer field-effect transistors},
     author = {Kyndiah, Adrica and Zemignani, Giulia Zoe and Ronchi, Carlotta and Tullii, Gabriele and Khudiakov, Aleksandr and Iachetta, Giuseppina and Chiodini, Stefano and Moreddu, Rosalia and Viola, Fabrizio Antonio and Schwartz, Peter J. and Gomila, Gabriel and De Angelis, Francesco and Sala, Luca and Antognazza, Maria Rosa and Caironi, Mario},
     journal = {Nature Communications},
     volume = {16},
     number = {1},
     pages = {8143},
     year = {2025},
     doi = {10.1038/s41467-025-63484-1},
     status = {corresponding},
     dimensions = {true}
   }

3. BJP

   Rescue of loss-of-function long QT syndrome-associated mutations in KV7.1/KCNE1 by the endocannabinoid N-arachidonoyl-L-serine (ARA-S)

   Irene Hiniesto-Iñigo, Akshay Sridhar, Julien Louradour, Alicia Cruz, Siri Lundholm, Amaia Jauregi-Miguel, Federica Giannetti, Luca Sala, Katja E Odening, H Peter Larsson, and  others

   British Journal of Pharmacology, 2025

   Bib DOI

   @article{hiniesto2025rescue,
     title = {Rescue of loss-of-function long QT syndrome-associated mutations in KV7.1/KCNE1 by the endocannabinoid N-arachidonoyl-L-serine (ARA-S)},
     author = {Hiniesto-I{\~n}igo, Irene and Sridhar, Akshay and Louradour, Julien and De la Cruz, Alicia and Lundholm, Siri and Jauregi-Miguel, Amaia and Giannetti, Federica and Sala, Luca and Odening, Katja E and Larsson, H Peter and others},
     journal = {British Journal of Pharmacology},
     volume = {182},
     number = {13},
     pages = {2861--2877},
     year = {2025},
     doi = {10.1111/bph.70008},
     dimensions = {true}
   }

4. LightSciApp

   Membrane-targeted push-pull azobenzenes for the optical modulation of membrane potential

   Valentina Sesti, Arianna Magni, Matteo Moschetta, Chiara Florindi, Marlene E Pfeffer, Mattia Lorenzo DiFrancesco, Michele Guizzardi, Giulia Folpini, Luca Sala, Alessandra Gilda Ritacca, Beatrice Campanelli, Paola Moretti, Giuseppe Maria Paternò, Luca Maragliano, Matteo Tommasini, Francesco Lodola, Elisabetta Colombo, Fabio Benfenati, Chiara Bertarelli, and Guglielmo Lanzani

   Light: Science & Applications, 2025

   Bib DOI

   @article{sesti2025membrane,
     title = {Membrane-targeted push-pull azobenzenes for the optical modulation of membrane potential},
     author = {Sesti, Valentina and Magni, Arianna and Moschetta, Matteo and Florindi, Chiara and Pfeffer, Marlene E and DiFrancesco, Mattia Lorenzo and Guizzardi, Michele and Folpini, Giulia and Sala, Luca and Ritacca, Alessandra Gilda and Campanelli, Beatrice and Moretti, Paola and Patern{\`o}, Giuseppe Maria and Maragliano, Luca and Tommasini, Matteo and Lodola, Francesco and Colombo, Elisabetta and Benfenati, Fabio and Bertarelli, Chiara and Lanzani, Guglielmo},
     journal = {Light: Science \& Applications},
     volume = {14},
     number = {1},
     pages = {8},
     year = {2025},
     doi = {10.1038/s41377-024-01669-x},
     dimensions = {true}
   }

2024

1. CellDeathDis

   Cardiomyocyte and stromal cell cross-talk influences the pathogenesis of arrhythmogenic cardiomyopathy: a multi-level analysis uncovers DLK1-NOTCH pathway role in fibro-adipose remodelling

   Angela Serena Maione, Lara Iengo, Luca Sala, Ilaria Massaiu, Mattia Chiesa, Melania Lippi, Stefania Ghilardi, Chiara Florindi, Francesco Lodola, Antonio Zaza, and  others

   Cell Death Discovery, 2024

   Bib DOI

   @article{maione2024cardiomyocyte,
     title = {Cardiomyocyte and stromal cell cross-talk influences the pathogenesis of arrhythmogenic cardiomyopathy: a multi-level analysis uncovers DLK1-NOTCH pathway role in fibro-adipose remodelling},
     author = {Maione, Angela Serena and Iengo, Lara and Sala, Luca and Massaiu, Ilaria and Chiesa, Mattia and Lippi, Melania and Ghilardi, Stefania and Florindi, Chiara and Lodola, Francesco and Zaza, Antonio and others},
     journal = {Cell Death Discovery},
     volume = {10},
     number = {1},
     pages = {484},
     year = {2024},
     publisher = {Nature Publishing Group UK London},
     doi = {10.1038/s41420-024-02232-8},
     dimensions = {true}
   }

2. Circ

   Multiplexed assays of variant effect and automated patch clamping improve KCNH2-LQTS variant classification and cardiac event risk stratification

   Matthew J O’Neill, Chai-Ann Ng, Takanori Aizawa, Luca Sala, Sahej Bains, Annika Winbo, Rizwan Ullah, Qianyi Shen, Chek-Ying Tan, Krystian Kozek, and  others

   Circulation, 2024

   Bib DOI

   @article{o2024multiplexed,
     title = {Multiplexed assays of variant effect and automated patch clamping improve KCNH2-LQTS variant classification and cardiac event risk stratification},
     author = {O'Neill, Matthew J and Ng, Chai-Ann and Aizawa, Takanori and Sala, Luca and Bains, Sahej and Winbo, Annika and Ullah, Rizwan and Shen, Qianyi and Tan, Chek-Ying and Kozek, Krystian and others},
     journal = {Circulation},
     volume = {150},
     number = {23},
     pages = {1869--1881},
     year = {2024},
     publisher = {Lippincott Williams \& Wilkins Hagerstown, MD},
     doi = {10.1161/CIRCULATIONAHA.124.069828},
     dimensions = {true}
   }

3. Circ

   Therapeutic efficacy of mexiletine for long QT syndrome type 2: evidence from human induced pluripotent stem cell–derived cardiomyocytes, transgenic rabbits, and patients

   Lia Crotti, Raquel Neves, Federica Dagradi, Giulia Musu, Federica Giannetti, J Martijn Bos, Miriam Barbieri, Paolo Cerea, Fulvio LF Giovenzana, Margherita Torchio, and  others

   Circulation, 2024

   Bib DOI

   @article{crotti2024therapeutic,
     title = {Therapeutic efficacy of mexiletine for long QT syndrome type 2: evidence from human induced pluripotent stem cell--derived cardiomyocytes, transgenic rabbits, and patients},
     author = {Crotti, Lia and Neves, Raquel and Dagradi, Federica and Musu, Giulia and Giannetti, Federica and Bos, J Martijn and Barbieri, Miriam and Cerea, Paolo and Giovenzana, Fulvio LF and Torchio, Margherita and others},
     journal = {Circulation},
     volume = {150},
     number = {7},
     pages = {531--543},
     year = {2024},
     publisher = {Lippincott Williams \& Wilkins Hagerstown, MD},
     doi = {10.1161/CIRCULATIONAHA.124.068959},
     dimensions = {true}
   }

4. FrontPhysiol

   Advances in pluripotent stem cell-based in vitro models of the human heart for cardiac physiology, disease modeling and clinical applications

   Maksymilian Prondzynski, Josè Manuel Pioner, Luca Sala, Milena Bellin, and Viviana Meraviglia

   Frontiers in Physiology, 2024

   Bib DOI

   @article{prondzynski2024advances,
     title = {Advances in pluripotent stem cell-based in vitro models of the human heart for cardiac physiology, disease modeling and clinical applications},
     author = {Prondzynski, Maksymilian and Pioner, Jos{\`e} Manuel and Sala, Luca and Bellin, Milena and Meraviglia, Viviana},
     journal = {Frontiers in Physiology},
     volume = {15},
     pages = {1378495},
     year = {2024},
     publisher = {Frontiers Media SA},
     doi = {10.3389/fphys.2024.1378495},
     dimensions = {true}
   }

5. Book

   The Dynamic Clamp Technique: A Robust Toolkit for Investigating Potassium Channel Function

   Chiara Bartolucci, and Luca Sala

   In Potassium Channels: Methods and Protocols, 2024

   Bib

   @incollection{bartolucci2024dynamic,
     title = {The Dynamic Clamp Technique: A Robust Toolkit for Investigating Potassium Channel Function},
     author = {Bartolucci, Chiara and Sala, Luca},
     booktitle = {Potassium Channels: Methods and Protocols},
     pages = {211--227},
     year = {2024},
     publisher = {Springer},
   }

2023

1. EHJ

   Clinical presentation of calmodulin mutations: the International Calmodulinopathy Registry

   Lia Crotti, Carla Spazzolini, Mette Nyegaard, Michael T Overgaard, Maria-Christina Kotta, Federica Dagradi, Luca Sala, Takeshi Aiba, Mark D Ayers, Anwar Baban, and  others

   European heart journal, 2023

   Bib DOI

   @article{crotti2023clinical,
     title = {Clinical presentation of calmodulin mutations: the International Calmodulinopathy Registry},
     author = {Crotti, Lia and Spazzolini, Carla and Nyegaard, Mette and Overgaard, Michael T and Kotta, Maria-Christina and Dagradi, Federica and Sala, Luca and Aiba, Takeshi and Ayers, Mark D and Baban, Anwar and others},
     journal = {European heart journal},
     volume = {44},
     number = {35},
     pages = {3357--3370},
     year = {2023},
     publisher = {Oxford University Press US},
     doi = {10.1093/eurheartj/ehad418},
     dimensions = {true}
   }

2. Europace

   Gene-and variant-specific efficacy of serum/glucocorticoid-regulated kinase 1 inhibition in long QT syndrome types 1 and 2

   Federica Giannetti, Miriam Barbieri, Assad Shiti, Simona Casini, Philip T Sager, Saumya Das, Sabindra Pradhananga, Dinesh Srinivasan, Saranda Nimani, Nicolò Alerni, and  others

   Europace, 2023

   Bib DOI

   @article{giannetti2023gene,
     title = {Gene-and variant-specific efficacy of serum/glucocorticoid-regulated kinase 1 inhibition in long QT syndrome types 1 and 2},
     author = {Giannetti, Federica and Barbieri, Miriam and Shiti, Assad and Casini, Simona and Sager, Philip T and Das, Saumya and Pradhananga, Sabindra and Srinivasan, Dinesh and Nimani, Saranda and Alerni, Nicol{\`o} and others},
     journal = {Europace},
     volume = {25},
     number = {5},
     pages = {euad094},
     year = {2023},
     publisher = {Oxford University Press US},
     doi = {10.1093/europace/euad094},
     status = {corresponding},
     dimensions = {true}
   }

3. CommBiol

   A dynamic clamping approach using in silico IK1 current for discrimination of chamber-specific hiPSC-derived cardiomyocytes

   Claudia Altomare, Chiara Bartolucci, Luca Sala, Carolina Balbi, Jacopo Burrello, Nicole Pietrogiovanna, Alessio Burrello, Sara Bolis, Stefano Panella, Martina Arici, and  others

   Communications Biology, 2023

   Bib DOI

   @article{altomare2023dynamic,
     title = {A dynamic clamping approach using in silico IK1 current for discrimination of chamber-specific hiPSC-derived cardiomyocytes},
     author = {Altomare, Claudia and Bartolucci, Chiara and Sala, Luca and Balbi, Carolina and Burrello, Jacopo and Pietrogiovanna, Nicole and Burrello, Alessio and Bolis, Sara and Panella, Stefano and Arici, Martina and others},
     journal = {Communications Biology},
     volume = {6},
     number = {1},
     pages = {291},
     year = {2023},
     publisher = {Nature Publishing Group UK London},
     doi = {10.1038/s42003-023-04674-9},
     dimensions = {true}
   }

4. CurrOpCard

   The impact of genetics on the long QT syndrome: myth or reality?

   Peter J Schwartz, and Luca Sala

   Current Opinion in Cardiology, 2023

   Bib DOI

   @article{schwartz2023impact,
     title = {The impact of genetics on the long QT syndrome: myth or reality?},
     author = {Schwartz, Peter J and Sala, Luca},
     journal = {Current Opinion in Cardiology},
     volume = {38},
     number = {3},
     pages = {149--156},
     year = {2023},
     publisher = {LWW},
     doi = {10.1097/HCO.0000000000001027},
     dimensions = {true}
   }

5. GenMed

   Continuous Bayesian variant interpretation accounts for incomplete penetrance among Mendelian cardiac channelopathies

   Matthew J O’Neill, Luca Sala, Isabelle Denjoy, Yuko Wada, Krystian Kozek, Lia Crotti, Federica Dagradi, Maria-Christina Kotta, Carla Spazzolini, Antoine Leenhardt, and  others

   Genetics in Medicine, 2023

   Bib DOI

   @article{o2023continuous,
     title = {Continuous Bayesian variant interpretation accounts for incomplete penetrance among Mendelian cardiac channelopathies},
     author = {O'Neill, Matthew J and Sala, Luca and Denjoy, Isabelle and Wada, Yuko and Kozek, Krystian and Crotti, Lia and Dagradi, Federica and Kotta, Maria-Christina and Spazzolini, Carla and Leenhardt, Antoine and others},
     journal = {Genetics in Medicine},
     volume = {25},
     number = {3},
     pages = {100355},
     year = {2023},
     publisher = {Elsevier},
     doi = {10.1016/j.gim.2022.12.002},
     dimensions = {true}
   }

6. bioRxiv

   Batch Action PoTential Analyser (BAPTA): an open source tool for automated high throughput analysis of cardiac action potentials

   Vladislav Leonov, Eleonora Torre, Carlotta Ronchi, Lia Crotti, Peter J Schwartz, Marcella Rocchetti, Antonio Zaza, and Luca Sala^#

   2023

   Bib DOI

   @preprint{leonov2023batch,
     title = {Batch Action PoTential Analyser (BAPTA): an open source tool for automated high throughput analysis of cardiac action potentials},
     author = {Leonov, Vladislav and Torre, Eleonora and Ronchi, Carlotta and Crotti, Lia and Schwartz, Peter J and Rocchetti, Marcella and Zaza, Antonio and Sala, Luca},
     journal = {bioRxiv},
     pages = {2023--03},
     year = {2023},
     publisher = {Cold Spring Harbor Laboratory},
     doi = {10.1101/2023.03.01.530103},
     status = {corresponding}
   }

7. bioRxiv

   Gain of chromosome region 1q31. 3 in human iPSCs confers growth advantage and alters contraction in derivative cardiomyocytes

   Karina O Brandão, Viviana Meraviglia, Daniela Salvatori, Xu Cao, Luca Sala, Loukia Yiangou, Mervyn PH Mol, Milena Bellin, Christine L Mummery, and Richard P Davis

   BioRxiv, 2023

   Bib

   @article{brandao2023gain,
     title = {Gain of chromosome region 1q31. 3 in human iPSCs confers growth advantage and alters contraction in derivative cardiomyocytes},
     author = {Brand{\~a}o, Karina O and Meraviglia, Viviana and Salvatori, Daniela and Cao, Xu and Sala, Luca and Yiangou, Loukia and Mol, Mervyn PH and Bellin, Milena and Mummery, Christine L and Davis, Richard P},
     journal = {BioRxiv},
     pages = {2023--12},
     year = {2023},
     publisher = {Cold Spring Harbor Laboratory},
   }

2022

1. FrontPhysiol

   Use of hiPSC-derived cardiomyocytes to rule out proarrhythmic effects of drugs: the case of hydroxychloroquine in COVID-19

   Luca Sala^#, Vladislav Leonov, Manuela Mura, Federica Giannetti, Aleksandr Khudiakov, Alessandra Moretti, Lia Crotti, Massimiliano Gnecchi, and Peter J Schwartz

   Frontiers in Physiology, 2022

   Bib DOI

   @article{sala2022use,
     title = {Use of hiPSC-derived cardiomyocytes to rule out proarrhythmic effects of drugs: the case of hydroxychloroquine in COVID-19},
     author = {Sala, Luca and Leonov, Vladislav and Mura, Manuela and Giannetti, Federica and Khudiakov, Aleksandr and Moretti, Alessandra and Crotti, Lia and Gnecchi, Massimiliano and Schwartz, Peter J},
     journal = {Frontiers in Physiology},
     volume = {12},
     pages = {730127},
     year = {2022},
     publisher = {Frontiers Media SA},
     doi = {10.3389/fphys.2021.730127},
     status = {corresponding},
     dimensions = {true}
   }

2021

1. CircGPM

   Estimating the posttest probability of long QT syndrome diagnosis for rare KCNH2 variants

   Krystian Kozek, Yuko Wada, Luca Sala, Isabelle Denjoy, Christian Egly, Matthew J O’Neill, Takeshi Aiba, Wataru Shimizu, Naomasa Makita, Taisuke Ishikawa, and  others

   Circulation: Genomic and Precision Medicine, 2021

   Bib DOI

   @article{kozek2021estimating,
     title = {Estimating the posttest probability of long QT syndrome diagnosis for rare KCNH2 variants},
     author = {Kozek, Krystian and Wada, Yuko and Sala, Luca and Denjoy, Isabelle and Egly, Christian and O'Neill, Matthew J and Aiba, Takeshi and Shimizu, Wataru and Makita, Naomasa and Ishikawa, Taisuke and others},
     journal = {Circulation: Genomic and Precision Medicine},
     volume = {14},
     number = {4},
     pages = {e003289},
     year = {2021},
     publisher = {Am Heart Assoc},
     doi = {10.1161/CIRCGEN.120.003289},
     dimensions = {true}
   }

2. CVR

   MTMR4 SNVs modulate ion channel degradation and clinical severity in congenital long QT syndrome: insights in the mechanism of action of protective modifier genes

   Yee-Ki Lee, Luca Sala^*, Manuela Mura, Marcella Rocchetti, Matteo Pedrazzini, Xinru Ran, Timothy SH Mak, Lia Crotti, Pak C Sham, Eleonora Torre, and  others

   Cardiovascular Research, 2021

   Bib DOI

   @article{lee2021mtmr4,
     title = {MTMR4 SNVs modulate ion channel degradation and clinical severity in congenital long QT syndrome: insights in the mechanism of action of protective modifier genes},
     author = {Lee, Yee-Ki and Sala, Luca and Mura, Manuela and Rocchetti, Marcella and Pedrazzini, Matteo and Ran, Xinru and Mak, Timothy SH and Crotti, Lia and Sham, Pak C and Torre, Eleonora and others},
     journal = {Cardiovascular Research},
     volume = {117},
     number = {3},
     pages = {767--779},
     year = {2021},
     publisher = {Oxford University Press},
     doi = {10.1093/cvr/cvaa019},
     status = {shared-first},
     dimensions = {true}
   }

3. SCR

   Generation and characterization of the human induced pluripotent stem cell (hiPSC) line NCUFi001-A from a patient carrying KCNQ1 G314S mutation

   Luca Lavra, Fiorenza Magi, Alessandra Ulivieri, Alessandra Morgante, Marianna Paulis, Luca Sala, Matteo Pedrazzini, Patrizio Polisca, Marcella Rocchetti, Leonardo Calò, and  others

   Stem Cell Research, 2021

   Bib DOI

   @article{lavra2021generation,
     title = {Generation and characterization of the human induced pluripotent stem cell (hiPSC) line NCUFi001-A from a patient carrying KCNQ1 G314S mutation},
     author = {Lavra, Luca and Magi, Fiorenza and Ulivieri, Alessandra and Morgante, Alessandra and Paulis, Marianna and Sala, Luca and Pedrazzini, Matteo and Polisca, Patrizio and Rocchetti, Marcella and Cal{\`o}, Leonardo and others},
     journal = {Stem Cell Research},
     volume = {54},
     pages = {102418},
     year = {2021},
     publisher = {Elsevier},
     doi = {10.1016/j.scr.2021.102418},
     dimensions = {true}
   }

4. EHJ

   Precision medicine and cardiac channelopathies: when dreams meet reality

   Massimiliano Gnecchi, Luca Sala^*, and Peter J Schwartz

   European heart journal, 2021

   Bib DOI

   @article{gnecchi2021precision,
     title = {Precision medicine and cardiac channelopathies: when dreams meet reality},
     author = {Gnecchi, Massimiliano and Sala, Luca and Schwartz, Peter J},
     journal = {European heart journal},
     volume = {42},
     number = {17},
     pages = {1661--1675},
     year = {2021},
     publisher = {Oxford University Press},
     doi = {10.1093/eurheartj/ehab007},
     status = {shared-first},
     dimensions = {true}
   }

5. BBRC

   Cardiac microtissues from human pluripotent stem cells recapitulate the phenotype of long-QT syndrome

   Elisa Giacomelli, Luca Sala^*, Dorien Ward-van Oostwaard, and Milena Bellin

   Biochemical and Biophysical Research Communications, 2021

   Bib DOI

   @article{giacomelli2021cardiac,
     title = {Cardiac microtissues from human pluripotent stem cells recapitulate the phenotype of long-QT syndrome},
     author = {Giacomelli, Elisa and Sala, Luca and Ward-van Oostwaard, Dorien and Bellin, Milena},
     journal = {Biochemical and Biophysical Research Communications},
     volume = {572},
     pages = {118--124},
     year = {2021},
     publisher = {Elsevier},
     doi = {10.1016/j.bbrc.2021.07.068},
     status = {shared-first},
     dimensions = {true}
   }

2020

1. CellStemCell

   Human-iPSC-derived cardiac stromal cells enhance maturation in 3D cardiac microtissues and reveal non-cardiomyocyte contributions to heart disease

   Elisa Giacomelli, Viviana Meraviglia, Giulia Campostrini, Amy Cochrane, Xu Cao, Ruben WJ Van Helden, Ana Krotenberg Garcia, Maria Mircea, Sarantos Kostidis, Richard P Davis, and  others

   Cell stem cell, 2020

   Bib DOI

   @article{giacomelli2020human,
     title = {Human-iPSC-derived cardiac stromal cells enhance maturation in 3D cardiac microtissues and reveal non-cardiomyocyte contributions to heart disease},
     author = {Giacomelli, Elisa and Meraviglia, Viviana and Campostrini, Giulia and Cochrane, Amy and Cao, Xu and Van Helden, Ruben WJ and Garcia, Ana Krotenberg and Mircea, Maria and Kostidis, Sarantos and Davis, Richard P and others},
     journal = {Cell stem cell},
     volume = {26},
     number = {6},
     pages = {862--879},
     year = {2020},
     publisher = {Elsevier},
     doi = {10.1016/j.stem.2020.05.004},
     dimensions = {true}
   }

2. StemCellRep

   Isogenic sets of hiPSC-CMs harboring distinct KCNH2 mutations differ functionally and in susceptibility to drug-induced arrhythmias

   Karina O Brandão, Lettine Brink, Duncan C Miller, Catarina Grandela, Berend J Meer, Mervyn PH Mol, Tessa Korte, Leon GJ Tertoolen, Christine L Mummery, Luca Sala, and  others

   Stem cell reports, 2020

   Bib DOI

   @article{brandao2020isogenic,
     title = {Isogenic sets of hiPSC-CMs harboring distinct KCNH2 mutations differ functionally and in susceptibility to drug-induced arrhythmias},
     author = {Brand{\~a}o, Karina O and van den Brink, Lettine and Miller, Duncan C and Grandela, Catarina and van Meer, Berend J and Mol, Mervyn PH and de Korte, Tessa and Tertoolen, Leon GJ and Mummery, Christine L and Sala, Luca and others},
     journal = {Stem cell reports},
     volume = {15},
     number = {5},
     pages = {1127--1139},
     year = {2020},
     publisher = {Elsevier},
     doi = {10.1016/j.stemcr.2020.10.005},
     dimensions = {true}
   }

2019

1. EHJ

   From patient-specific induced pluripotent stem cells to clinical translation in long QT syndrome Type 2

   Peter J Schwartz, Massimiliano Gnecchi, Federica Dagradi, Silvia Castelletti, Gianfranco Parati, Carla Spazzolini, Luca Sala, and Lia Crotti

   European heart journal, 2019

   Bib DOI

   @article{schwartz2019patient,
     title = {From patient-specific induced pluripotent stem cells to clinical translation in long QT syndrome Type 2},
     author = {Schwartz, Peter J and Gnecchi, Massimiliano and Dagradi, Federica and Castelletti, Silvia and Parati, Gianfranco and Spazzolini, Carla and Sala, Luca and Crotti, Lia},
     journal = {European heart journal},
     volume = {40},
     number = {23},
     pages = {1832--1836},
     year = {2019},
     publisher = {Oxford University Press},
     doi = {10.1093/eurheartj/ehz023},
     dimensions = {true}
   }

2. AER

   Long QT syndrome modelling with cardiomyocytes derived from human-induced pluripotent stem cells

   Luca Sala, Massimiliano Gnecchi, and Peter J Schwartz

   Arrhythmia & electrophysiology review, 2019

   Bib DOI

   @article{sala2019long,
     title = {Long QT syndrome modelling with cardiomyocytes derived from human-induced pluripotent stem cells},
     author = {Sala, Luca and Gnecchi, Massimiliano and Schwartz, Peter J},
     journal = {Arrhythmia \& electrophysiology review},
     volume = {8},
     number = {2},
     pages = {105},
     year = {2019},
     doi = {10.15420/aer.2019.1.1},
     dimensions = {true}
   }

3. CircRes

   Precision Versus Traditional Medicine—Clinical Questions Trigger Progress in Basic Science: A Favor Not Always Returned

   Peter J Schwartz, and Luca Sala

   Circulation Research, 2019

   Bib DOI

   @article{schwartz2019precision,
     title = {Precision Versus Traditional Medicine—Clinical Questions Trigger Progress in Basic Science: A Favor Not Always Returned},
     author = {Schwartz, Peter J and Sala, Luca},
     journal = {Circulation Research},
     volume = {124},
     number = {4},
     pages = {459--461},
     year = {2019},
     publisher = {Am Heart Assoc},
     doi = {10.1161/CIRCRESAHA.119.314629},
     dimensions = {true}
   }

4. NatComm

   Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes

   Berend J Van Meer, Ana Krotenberg, Luca Sala, Richard P Davis, Thomas Eschenhagen, Chris Denning, Leon GJ Tertoolen, and Christine L Mummery

   Nature communications, 2019

   Bib DOI

   @article{van2019simultaneous,
     title = {Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes},
     author = {Van Meer, Berend J and Krotenberg, Ana and Sala, Luca and Davis, Richard P and Eschenhagen, Thomas and Denning, Chris and Tertoolen, Leon GJ and Mummery, Christine L},
     journal = {Nature communications},
     volume = {10},
     number = {1},
     pages = {4325},
     year = {2019},
     publisher = {Nature Publishing Group UK London},
     doi = {10.1038/s41467-019-12354-8},
     dimensions = {true}
   }

5. Book

   Cardiac repolarization and stem cells: an emerging path toward precision medicine

   Massimiliano Gnecchi, Luca Sala, and Peter J Schwartz

   In Cardiac Repolarization: Basic Science and Clinical Management, 2019

   Bib

   @incollection{gnecchi2019cardiac,
     title = {Cardiac repolarization and stem cells: an emerging path toward precision medicine},
     author = {Gnecchi, Massimiliano and Sala, Luca and Schwartz, Peter J},
     booktitle = {Cardiac Repolarization: Basic Science and Clinical Management},
     pages = {87--107},
     year = {2019},
     publisher = {Springer International Publishing Cham},
   }

6. bioRxiv

   Isogenic sets of hiPSC-CMs harboring KCNH2 mutations capture location-related phenotypic differences

   Karina O Brandão, Lettine Brink, Duncan C Miller, Catarina Grandela, Berend J Meer, Mervyn PH Mol, Leon GJ Tertoolen, Christine L Mummery, Luca Sala, Arie O Verkerk, and  others

   bioRxiv, 2019

   Bib

   @article{brandao2019isogenic,
     title = {Isogenic sets of hiPSC-CMs harboring KCNH2 mutations capture location-related phenotypic differences},
     author = {Brand{\~a}o, Karina O and van den Brink, Lettine and Miller, Duncan C and Grandela, Catarina and van Meer, Berend J and Mol, Mervyn PH and Tertoolen, Leon GJ and Mummery, Christine L and Sala, Luca and Verkerk, Arie O and others},
     journal = {bioRxiv},
     pages = {846519},
     year = {2019},
     publisher = {Cold Spring Harbor Laboratory},
   }

2018

1. CircRes

   MUSCLEMOTION: a versatile open software tool to quantify cardiomyocyte and cardiac muscle contraction in vitro and in vivo

   Luca Sala^*, Berend J Van Meer, Leon GJ Tertoolen, Jeroen Bakkers, Milena Bellin, Richard P Davis, Chris Denning, Michel AE Dieben, Thomas Eschenhagen, Elisa Giacomelli, and  others

   Circulation research, 2018

   Bib DOI

   @article{sala2018musclemotion,
     title = {MUSCLEMOTION: a versatile open software tool to quantify cardiomyocyte and cardiac muscle contraction in vitro and in vivo},
     author = {Sala, Luca and Van Meer, Berend J and Tertoolen, Leon GJ and Bakkers, Jeroen and Bellin, Milena and Davis, Richard P and Denning, Chris and Dieben, Michel AE and Eschenhagen, Thomas and Giacomelli, Elisa and others},
     journal = {Circulation research},
     volume = {122},
     number = {3},
     pages = {e5--e16},
     year = {2018},
     publisher = {Am Heart Assoc},
     doi = {10.1161/CIRCRESAHA.117.312067},
     status = {shared-first},
     dimensions = {true}
   }

2. Europace

   Action potential contour contributes to species differences in repolarization response to β-adrenergic stimulation

   Luca Sala^*, Bence Hegyi, Chiara Bartolucci, Claudia Altomare, Marcella Rocchetti, Krisztina Váczi, Gaspare Mostacciuolo, Norbert Szentandrássy, Stefano Severi, Péter Pál Nánási, and  others

   EP Europace, 2018

   Bib DOI

   @article{sala2018action,
     title = {Action potential contour contributes to species differences in repolarization response to $\beta$-adrenergic stimulation},
     author = {Sala, Luca and Hegyi, Bence and Bartolucci, Chiara and Altomare, Claudia and Rocchetti, Marcella and V{\'a}czi, Krisztina and Mostacciuolo, Gaspare and Szentandr{\'a}ssy, Norbert and Severi, Stefano and P{\'a}l N{\'a}n{\'a}si, P{\'e}ter and others},
     journal = {EP Europace},
     volume = {20},
     number = {9},
     pages = {1543--1552},
     year = {2018},
     publisher = {Oxford University Press},
     doi = {10.1093/europace/eux236},
     status = {shared-first},
     dimensions = {true}
   }

3. CurrProt

   Quantification of muscle contraction in vitro and in vivo using MUSCLEMOTION software: from stem cell-derived cardiomyocytes to zebrafish and human hearts

   Berend J Meer, Luca Sala^*, Leon GJ Tertoolen, Godfrey L Smith, Francis L Burton, and Christine L Mummery

   Current Protocols in Human Genetics, 2018

   Bib DOI

   @article{van2018quantification,
     title = {Quantification of muscle contraction in vitro and in vivo using MUSCLEMOTION software: from stem cell-derived cardiomyocytes to zebrafish and human hearts},
     author = {van Meer, Berend J and Sala, Luca and Tertoolen, Leon GJ and Smith, Godfrey L and Burton, Francis L and Mummery, Christine L},
     journal = {Current Protocols in Human Genetics},
     volume = {99},
     number = {1},
     pages = {e67},
     year = {2018},
     doi = {10.1002/cphg.67},
     status = {shared-first},
     dimensions = {true}
   }

4. FrontCVM

   Calmodulinopathy: a novel, life-threatening clinical entity affecting the young

   Maria-Christina Kotta, Luca Sala^*, Alice Ghidoni, Beatrice Badone, Carlotta Ronchi, Gianfranco Parati, Antonio Zaza, and Lia Crotti

   Frontiers in cardiovascular medicine, 2018

   Bib DOI

   @article{kotta2018calmodulinopathy,
     title = {Calmodulinopathy: a novel, life-threatening clinical entity affecting the young},
     author = {Kotta, Maria-Christina and Sala, Luca and Ghidoni, Alice and Badone, Beatrice and Ronchi, Carlotta and Parati, Gianfranco and Zaza, Antonio and Crotti, Lia},
     journal = {Frontiers in cardiovascular medicine},
     volume = {5},
     pages = {175},
     year = {2018},
     publisher = {Frontiers Media SA},
     doi = {10.3389/fcvm.2018.00175},
     status = {shared-first},
     dimensions = {true}
   }

5. FrontCVM

   Calmodulinopathy: functional effects of CALM mutations and their relationship with clinical phenotypes

   Beatrice Badone, Carlotta Ronchi, Maria-Christina Kotta, Luca Sala, Alice Ghidoni, Lia Crotti, and Antonio Zaza

   Frontiers in Cardiovascular Medicine, 2018

   Bib DOI

   @article{badone2018calmodulinopathy,
     title = {Calmodulinopathy: functional effects of CALM mutations and their relationship with clinical phenotypes},
     author = {Badone, Beatrice and Ronchi, Carlotta and Kotta, Maria-Christina and Sala, Luca and Ghidoni, Alice and Crotti, Lia and Zaza, Antonio},
     journal = {Frontiers in Cardiovascular Medicine},
     volume = {5},
     pages = {176},
     year = {2018},
     publisher = {Frontiers Media SA},
     doi = {10.3389/fcvm.2018.00176},
     dimensions = {true}
   }

2017

1. JoVE

   Electrophysiological analysis of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) using multi-electrode arrays (MEAs)

   Luca Sala, Dorien Ward-van Oostwaard, Leon GJ Tertoolen, Christine L Mummery, and Milena Bellin

   Journal of visualized experiments: JoVE, 2017

   Bib DOI

   @article{sala2017electrophysiological,
     title = {Electrophysiological analysis of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) using multi-electrode arrays (MEAs)},
     author = {Sala, Luca and Ward-van Oostwaard, Dorien and Tertoolen, Leon GJ and Mummery, Christine L and Bellin, Milena},
     journal = {Journal of visualized experiments: JoVE},
     number = {123},
     pages = {55587},
     year = {2017},
     doi = {10.3791/55587},
   }

2. CVR

   Elucidating arrhythmogenic mechanisms of long-QT syndrome CALM1-F142L mutation in patient-specific induced pluripotent stem cell-derived cardiomyocytes

   Marcella Rocchetti, Luca Sala^*, Lisa Dreizehnter, Lia Crotti, Daniel Sinnecker, Manuela Mura, Luna Simona Pane, Claudia Altomare, Eleonora Torre, Gaspare Mostacciuolo, and  others

   Cardiovascular research, 2017

   Bib DOI

   @article{rocchetti2017elucidating,
     title = {Elucidating arrhythmogenic mechanisms of long-QT syndrome CALM1-F142L mutation in patient-specific induced pluripotent stem cell-derived cardiomyocytes},
     author = {Rocchetti, Marcella and Sala, Luca and Dreizehnter, Lisa and Crotti, Lia and Sinnecker, Daniel and Mura, Manuela and Pane, Luna Simona and Altomare, Claudia and Torre, Eleonora and Mostacciuolo, Gaspare and others},
     journal = {Cardiovascular research},
     volume = {113},
     number = {5},
     pages = {531--541},
     year = {2017},
     publisher = {Oxford University Press},
     doi = {10.1093/cvr/cvx006},
     status = {shared-first},
     dimensions = {true}
   }

3. Dev

   Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells

   Elisa Giacomelli, Milena Bellin, Luca Sala, Berend J Van Meer, Leon GJ Tertoolen, Valeria V Orlova, and Christine L Mummery

   Development, 2017

   Bib DOI

   @article{giacomelli2017three,
     title = {Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells},
     author = {Giacomelli, Elisa and Bellin, Milena and Sala, Luca and Van Meer, Berend J and Tertoolen, Leon GJ and Orlova, Valeria V and Mummery, Christine L},
     journal = {Development},
     volume = {144},
     number = {6},
     pages = {1008--1017},
     year = {2017},
     publisher = {The Company of Biologists Ltd},
     doi = {10.1242/dev.143438},
     dimensions = {true}
   }

4. BJP

   Integrating cardiomyocytes from human pluripotent stem cells in safety pharmacology: has the time come?

   Luca Sala, Milena Bellin, and Christine L Mummery

   British journal of pharmacology, 2017

   Bib DOI

   @article{sala2017integrating,
     title = {Integrating cardiomyocytes from human pluripotent stem cells in safety pharmacology: has the time come?},
     author = {Sala, Luca and Bellin, Milena and Mummery, Christine L},
     journal = {British journal of pharmacology},
     volume = {174},
     number = {21},
     pages = {3749--3765},
     year = {2017},
     publisher = {Wiley Online Library},
     doi = {10.1111/bph.13577},
     dimensions = {true}
   }

2016

1. EMBO MM

   A new hERG allosteric modulator rescues genetic and drug-induced long-QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells

   Luca Sala, Zhiyi Yu, Dorien Ward-van Oostwaard, Jacobus PD Veldhoven, Alessandra Moretti, Karl-Ludwig Laugwitz, Christine L Mummery, Adriaan P IJzerman, and Milena Bellin

   EMBO molecular medicine, 2016

   Bib DOI

   @article{sala2016new,
     title = {A new hERG allosteric modulator rescues genetic and drug-induced long-QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells},
     author = {Sala, Luca and Yu, Zhiyi and Ward-van Oostwaard, Dorien and van Veldhoven, Jacobus PD and Moretti, Alessandra and Laugwitz, Karl-Ludwig and Mummery, Christine L and IJzerman, Adriaan P and Bellin, Milena},
     journal = {EMBO molecular medicine},
     volume = {8},
     number = {9},
     pages = {1065--1081},
     year = {2016},
     doi = {10.15252/emmm.201606260},
     dimensions = {true}
   }

2015

1. CircAE

   I Kr impact on repolarization and its variability assessed by dynamic clamp

   Claudia Altomare, Chiara Bartolucci, Luca Sala, Joyce Bernardi, Gaspare Mostacciuolo, Marcella Rocchetti, Stefano Severi, and Antonio Zaza

   Circulation: Arrhythmia and Electrophysiology, 2015

   Bib DOI

   @article{altomare2015kr,
     title = {I Kr impact on repolarization and its variability assessed by dynamic clamp},
     author = {Altomare, Claudia and Bartolucci, Chiara and Sala, Luca and Bernardi, Joyce and Mostacciuolo, Gaspare and Rocchetti, Marcella and Severi, Stefano and Zaza, Antonio},
     journal = {Circulation: Arrhythmia and Electrophysiology},
     volume = {8},
     number = {5},
     pages = {1265--1275},
     year = {2015},
     publisher = {Am Heart Assoc},
     doi = {10.1161/CIRCEP.114.002572},
     dimensions = {true}
   }

2. PflArch

   Late sodium current (INaL) in pancreatic β-cells

   Riccardo Rizzetto, Marcella Rocchetti, Luca Sala, Carlotta Ronchi, Alice Villa, Mara Ferrandi, Isabella Molinari, Federico Bertuzzi, and Antonio Zaza

   Pflügers Archiv-European Journal of Physiology, 2015

   Bib DOI

   @article{rizzetto2015late,
     title = {Late sodium current (INaL) in pancreatic $\beta$-cells},
     author = {Rizzetto, Riccardo and Rocchetti, Marcella and Sala, Luca and Ronchi, Carlotta and Villa, Alice and Ferrandi, Mara and Molinari, Isabella and Bertuzzi, Federico and Zaza, Antonio},
     journal = {Pfl{\"u}gers Archiv-European Journal of Physiology},
     volume = {467},
     number = {8},
     pages = {1757--1768},
     year = {2015},
     publisher = {Springer Berlin Heidelberg Berlin/Heidelberg},
     doi = {10.1007/s00424-014-1613-0},
     dimensions = {true}
   }

2014

1. CVR

   Ranolazine prevents I NaL enhancement and blunts myocardial remodelling in a model of pulmonary hypertension

   Marcella Rocchetti, Luca Sala^*, Riccardo Rizzetto, Lidia Irene Staszewsky, Matteo Alemanni, Vanessa Zambelli, Ilaria Russo, Lucio Barile, Laura Cornaghi, Claudia Altomare, and  others

   Cardiovascular research, 2014

   Bib DOI

   @article{rocchetti2014ranolazine,
     title = {Ranolazine prevents I NaL enhancement and blunts myocardial remodelling in a model of pulmonary hypertension},
     author = {Rocchetti, Marcella and Sala, Luca and Rizzetto, Riccardo and Staszewsky, Lidia Irene and Alemanni, Matteo and Zambelli, Vanessa and Russo, Ilaria and Barile, Lucio and Cornaghi, Laura and Altomare, Claudia and others},
     journal = {Cardiovascular research},
     volume = {104},
     number = {1},
     pages = {37--48},
     year = {2014},
     publisher = {Oxford University Press},
     doi = {10.1093/cvr/cvu188},
     status = {shared-first},
     dimensions = {true}
   }

2013

1. JCMM

   Altered functional differentiation of mesoangioblasts in a genetic myopathy

   Claudia Altomare, Lucio Barile, Marcella Rocchetti, Luca Sala, Stefania Crippa, Maurilio Sampaolesi, and Antonio Zaza

   Journal of Cellular and Molecular Medicine, 2013

   Bib DOI

   @article{altomare2013altered,
     title = {Altered functional differentiation of mesoangioblasts in a genetic myopathy},
     author = {Altomare, Claudia and Barile, Lucio and Rocchetti, Marcella and Sala, Luca and Crippa, Stefania and Sampaolesi, Maurilio and Zaza, Antonio},
     journal = {Journal of Cellular and Molecular Medicine},
     volume = {17},
     number = {3},
     pages = {419--428},
     year = {2013},
     doi = {10.1111/jcmm.12023},
     dimensions = {true}
   }

2012

1. CDD

   Post-natal cardiomyocytes can generate iPS cells with an enhanced capacity toward cardiomyogenic re-differentation

   R Rizzi, E Di Pasquale, P Portararo, R Papait, P Cattaneo, MVG Latronico, C Altomare, L Sala , A Zaza, E Hirsch, and  others

   Cell Death & Differentiation, 2012

   Bib DOI

   @article{rizzi2012post,
     title = {Post-natal cardiomyocytes can generate iPS cells with an enhanced capacity toward cardiomyogenic re-differentation},
     author = {Rizzi, R and Di Pasquale, E and Portararo, P and Papait, R and Cattaneo, P and Latronico, MVG and Altomare, C and Sala, L and Zaza, A and Hirsch, E and others},
     journal = {Cell Death \& Differentiation},
     volume = {19},
     number = {7},
     pages = {1162--1174},
     year = {2012},
     publisher = {Nature Publishing Group},
     doi = {10.1038/cdd.2011.205},
     dimensions = {true}
   }